Title : Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice.

Pub. Date : 2013 Jun 13

PMID : 23764200






1 Functional Relationships(s)
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1 Drugs that activate RXRs, including bexarotene, can increase APOE and ABCA1 production, and have been shown to decrease the Abeta burden and improve cognition in mouse models of Abeta amyloidosis. Bexarotene apolipoprotein E Mus musculus