Title : Cytocompatibility and P-glycoprotein inhibition of block copolymers: structure-activity relationship.

Pub. Date : 2013 Aug 5

PMID : 23763603






2 Functional Relationships(s)
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1 Moreover, some of the tested copolymers (e.g., BO12EO227BO12 and EO57PO46EO57 that notably increased and C16EO455C16 that decreased the P-gp ATPase activity) were observed to act as efficient inhibitors of the P-gp efflux pump promoting an enhanced doxorubicin (DOXO) accumulation inside multidrug resistant (MDR) NCI-ADR-RES cells. copolymers phosphoglycolate phosphatase Homo sapiens
2 Moreover, some of the tested copolymers (e.g., BO12EO227BO12 and EO57PO46EO57 that notably increased and C16EO455C16 that decreased the P-gp ATPase activity) were observed to act as efficient inhibitors of the P-gp efflux pump promoting an enhanced doxorubicin (DOXO) accumulation inside multidrug resistant (MDR) NCI-ADR-RES cells. copolymers phosphoglycolate phosphatase Homo sapiens