Title : A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast.

Pub. Date : 2013

PMID : 23762324






1 Functional Relationships(s)
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1 These findings demonstrate that aPL, via TLR4 activation, induce a uric acid response in human trophoblast, which in turn activates the Nalp3/ASC inflammasome leading to IL-1beta processing and secretion. Uric Acid NLR family pyrin domain containing 3 Homo sapiens