Pub. Date : 2013 Jun 10
PMID : 23758830
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we studied the effect of local anesthetic tetracaine on ASIC currents. | Tetracaine | acid-sensing (proton-gated) ion channel 1 | Mus musculus |
| 2 | In addition to ASIC3, tetracaine inhibited the ASIC1a and ASIC1beta currents. | Tetracaine | acid-sensing (proton-gated) ion channel 1 | Mus musculus |
| 3 | In cultured mouse dorsal root ganglion neurons, 1-3 mM tetracaine inhibited both the transient and sustained ASIC currents. | Tetracaine | acid-sensing (proton-gated) ion channel 1 | Mus musculus |
| 4 | At pH4.5, 3 mM tetracaine reduced the peak ASIC current to 60.06 +- 4.51%, and the sustained current to 48.24 +- 7.02% of the control values in dorsal root ganglion neurons. | Tetracaine | acid-sensing (proton-gated) ion channel 1 | Mus musculus |