Pub. Date : 2013 Sep 1
PMID : 23752977
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GW0742, at 20 mg kg(-1) day(-1), attenuated ET-1 contraction by increasing RGS5 expression and restored the intracellular redox balance by reducing NADPH-oxidase activity, and by increasing the antioxidant genes expression. | GW0742 | endothelin 1 | Rattus norvegicus |
| 2 | CONCLUSION: Vascular protective effects of GW0742 operate via PPAR-beta by interference with the ET-1 signalling as a result of increased expression of RGS5 and up-regulation of antioxidant genes and via PPAR-beta-independent mechanisms to decrease blood pressure. | GW0742 | endothelin 1 | Rattus norvegicus |