Title : mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling.

Pub. Date : 2013 Oct

PMID : 23752093






2 Functional Relationships(s)
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1 Moreover, GABABR can activate mTOR and increase mTOR dependent expression of BDNF under the same NMDAR blocked conditions. gababr brain derived neurotrophic factor Homo sapiens
2 In vivo, blocking GABABR prevents the fast-acting, anti-depressant effect of the NR2B antagonist, Ro-25-6891, decreases active mTORC1 kinase, and reduces expression of BDNF and the AMPA receptor subunit GluA1. gababr brain derived neurotrophic factor Homo sapiens