Title : PIP3 but not PIP2 increases GLUT4 surface expression and glucose metabolism mediated by AKT/PKCζ/λ phosphorylation in 3T3L1 adipocytes.

Pub. Date : 2013 Sep

PMID : 23749168






1 Functional Relationships(s)
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1 Exogenous PIP3 supplementation (1, 5, or 10 nM) increased the phosphorylation of AKT and PKCzeta/lambda, which in turn upregulated GLUT4 total protein expression as well as its surface expression, glucose uptake, and glucose utilization in cells exposed to HG (25 mM); however, PIP2 had no effect. Phosphatidylinositol 4,5-Diphosphate thymoma viral proto-oncogene 1 Mus musculus