Pub. Date : 2013 Oct 1
PMID : 23747687
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. | isoliquiritigenin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Here, we demonstrate that isoliquiritigenin, a flavonoid phytoestrogen from licorice, induces growth inhibition and apoptosis through downregulating multiple key enzymes in AA metabolic network and the deactivation of PI3K/Akt in human breast cancer. | isoliquiritigenin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Conversely, the addition of exogenous eicosanoids, including PGE2, LTB4 and a 20-HETE analog (WIT003), and caspase inhibitors, or overexpression of constitutively active Akt reversed isoliquiritigenin-induced apoptosis. | isoliquiritigenin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Collectively, these data suggest that isoliquiritigenin induces growth inhibition and apoptosis through downregulating AA metabolic network and the deactivation of PI3K/Akt in human breast cancer. | isoliquiritigenin | AKT serine/threonine kinase 1 | Homo sapiens |