Pub. Date : 2013 Aug 1
PMID : 23744837
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious and well-tolerated treatment in endometrial cancer. | Progesterone | progesterone receptor | Mus musculus |
| 2 | Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious and well-tolerated treatment in endometrial cancer. | Progesterone | progesterone receptor | Mus musculus |
| 3 | Stromal deletion of PR as a single genetic change in these tumors induced progesterone resistance indicating that paracrine signaling through the stroma is essential for the progesterone therapeutic effects. | Progesterone | progesterone receptor | Mus musculus |
| 4 | Stromal deletion of PR as a single genetic change in these tumors induced progesterone resistance indicating that paracrine signaling through the stroma is essential for the progesterone therapeutic effects. | Progesterone | progesterone receptor | Mus musculus |
| 5 | Add-back of stromal PR expressed from a constitutively active promoter sensitized these tumors to progesterone therapy. | Progesterone | progesterone receptor | Mus musculus |
| 6 | Our findings suggest that epigenetic derepression of stromal PR could be a potential therapeutic target for sensitizing hormone-refractory endometrial tumors to progesterone therapy. | Progesterone | progesterone receptor | Mus musculus |