Pub. Date : 2013 Nov
PMID : 23744703
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Andrographolide suppresses high glucose-induced fibronectin expression in mesangial cells via inhibiting the AP-1 pathway. | andrographolide | fibronectin 1 | Homo sapiens |
| 2 | Andrographolide significantly decreased high glucose-induced cell proliferation and FN expression in MCs. | andrographolide | fibronectin 1 | Homo sapiens |
| 3 | EMSA assay demonstrated that increased AP-1 binding to an AP-1 binding site at -1,029 in the FN gene promoter upon high glucose stimulation, and the binding were disrupted by andrographolide treatment. | andrographolide | fibronectin 1 | Homo sapiens |
| 4 | These data indicate that andrographolide suppresses high glucose-induced FN expression by inhibiting AP-1-mediated pathway. | andrographolide | fibronectin 1 | Homo sapiens |