Pub. Date : 2013 Jul
PMID : 23738730
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | (S)-[6]-Gingerol inhibits TGF-beta-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. | gingerol | transforming growth factor beta 1 | Homo sapiens |
| 2 | We evaluated the effects of (S)-[6]-gingerol on these TGF-beta-mediated proteoglycan changes to explore its potential as an anti-atherosclerotic agent. | gingerol | transforming growth factor beta 1 | Homo sapiens |
| 3 | Biglycan level was assessed by real-time quantitative polymerase chain reactions and the effects of (S)-[6]-gingerol on TGF-beta signalling by assessment of the phosphorylation of Smads and Akt by western blotting. | gingerol | transforming growth factor beta 1 | Homo sapiens |
| 4 | KEY FINDINGS: (S)-[6]-Gingerol concentration-dependently inhibited TGF-beta-stimulated proteoglycan core protein synthesis, and this was not secondary to inhibition of total protein synthesis. | gingerol | transforming growth factor beta 1 | Homo sapiens |
| 5 | CONCLUSIONS: The activity of (S)-[6]-gingerol to inhibit TGF-beta-stimulated biglycan synthesis suggests a potential role for ginger in the prevention of atherosclerosis or other lipid-binding diseases. | gingerol | transforming growth factor beta 1 | Homo sapiens |
| 6 | The signalling studies indicate a novel site of action of (S)-[6]-gingerol in inhibiting TGF-beta responses. | gingerol | transforming growth factor beta 1 | Homo sapiens |