Pub. Date : 2012 Dec
PMID : 23730255
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria. | Hydrogen Peroxide | insulin receptor | Homo sapiens |
| 2 | Insulin-induced H2O2 promotes insulin receptor activation and the mitochondria act as the insulin-sensitive H2O2 source, providing a direct molecular link between mitochondrial dysfunction and irregular insulin receptor activation. | Hydrogen Peroxide | insulin receptor | Homo sapiens |
| 3 | Insulin-induced H2O2 promotes insulin receptor activation and the mitochondria act as the insulin-sensitive H2O2 source, providing a direct molecular link between mitochondrial dysfunction and irregular insulin receptor activation. | Hydrogen Peroxide | insulin receptor | Homo sapiens |
| 4 | Insulin-induced H2O2 promotes insulin receptor activation and the mitochondria act as the insulin-sensitive H2O2 source, providing a direct molecular link between mitochondrial dysfunction and irregular insulin receptor activation. | Hydrogen Peroxide | insulin receptor | Homo sapiens |
| 5 | Due to the high significance of insulin-induced H2O2 for insulin receptor activation, oxidative stress-induced upregulation of antioxidant enzymes, e.g., in AD brains, may represent another risk factor contributing to the development of insulin resistance. | Hydrogen Peroxide | insulin receptor | Homo sapiens |
| 6 | As insulin-induced H2O2 signalling requires fully functional mitochondria, pharmacological strategies based on activating mitochondria biogenesis in the brain are central to the treatment of diseases associated with dysfunctional insulin receptor signalling in this organ. | Hydrogen Peroxide | insulin receptor | Homo sapiens |