Title : Differential anti-tumor activities of curcumin against Ras- and Src-activated human adenocarcinoma cells.

Pub. Date : 2013 Jun 28

PMID : 23726918






2 Functional Relationships(s)
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1 Curcumin enhanced Erk1/2 predominantly in Ras-activated cells, but inhibited Akt and its downstream molecules (mTOR and S6K1) regardless of these oncogene activations. Curcumin mitogen-activated protein kinase 3 Homo sapiens
2 By contrast, drastic increases of G2/M cell populations were seen in Ras-activated cells rather than Src-activated cells, suggesting a potential role of Ras/Erk1/2 activation in curcumin-induced G2/M arrest. Curcumin mitogen-activated protein kinase 3 Homo sapiens