Pub. Date : 2013 Jul
PMID : 23726275
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1alpha. | Deferoxamine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 2 | Compared to the vehicle or VEGF treatment, DFO significantly increased neovascularization through up-regulation of HIF-1alpha and target genes including VEGF and stromal cell-derived factor-1alpha (SDF-1alpha). | Deferoxamine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 3 | In addition, DFO promoted the angiogenic-associated processes of endothelial tube formation, cell proliferation and migration in HIF-1alpha dependent manner. | Deferoxamine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 4 | CONCLUSIONS: DFO enhances neovascularization and accelerates diabetic wound healing through the accumulation of HIF-1alpha and the regulation of endothelial cell function. | Deferoxamine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |