Pub. Date : 2013 Aug
PMID : 23722590
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrogen peroxide (H2O2) induced a concentration-dependent increase in DNA breakage, PARP activation, depletion of intracellular ATP, inhibition of mitochondrial activity and two distinct parameters that quantify the breakdown of plasma membrane integrity (propidium iodide uptake or lactate dehydrogenase release). | Hydrogen Peroxide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Hydrogen peroxide (H2O2) induced a concentration-dependent increase in DNA breakage, PARP activation, depletion of intracellular ATP, inhibition of mitochondrial activity and two distinct parameters that quantify the breakdown of plasma membrane integrity (propidium iodide uptake or lactate dehydrogenase release). | Hydrogen Peroxide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | PARP-1 activation played a significant role in the H2O2-induced cell death response because PARP activation, depletion of intracellular ATP, inhibition of mitochondrial activity, and the breakdown of plasma membrane integrity were attenuated in cells with permanently silenced PARP-1. | Hydrogen Peroxide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | PARP-1 activation played a significant role in the H2O2-induced cell death response because PARP activation, depletion of intracellular ATP, inhibition of mitochondrial activity, and the breakdown of plasma membrane integrity were attenuated in cells with permanently silenced PARP-1. | Hydrogen Peroxide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 5 | PARP-1 activation played a significant role in the H2O2-induced cell death response because PARP activation, depletion of intracellular ATP, inhibition of mitochondrial activity, and the breakdown of plasma membrane integrity were attenuated in cells with permanently silenced PARP-1. | Hydrogen Peroxide | poly(ADP-ribose) polymerase 1 | Homo sapiens |