Title : Increased expression of p21Waf1/Cip1 and JNK with costimulation of prostate cancer cell activation by an siRNA Egr-1 inhibitor.

Pub. Date : 2013 Aug

PMID : 23715767






2 Functional Relationships(s)
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1 The expression of Egr-1, p21 and JNK was strongly increased after treatment of the cells with TPA, tumor necrosis factor-alpha (TNF-alpha) or arsenite. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens
2 Suppression of Egr-1 expression by siRNA abrogated the ability of TPA to induce Egr-1 and JNK-1 activities, moderately increasing the p21 activity and abrogating the anti-apoptotic effect of Egr-1 observed in the prostate cancer cell lines. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens