Title : The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia.

Pub. Date : 2013

PMID : 23714533






4 Functional Relationships(s)
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1 Recently, selective and potent FLT3 inhibitors such as AC220 (quizartinib) have proven clinically effective in patients with AML with FLT3 internal tandem duplication (ITD) mutations, but inhibitors of other pathologically activated kinases in AML such as c-KIT and JAK2 have achieved less clinical success. quizartinib fms related receptor tyrosine kinase 3 Homo sapiens
2 Recently, selective and potent FLT3 inhibitors such as AC220 (quizartinib) have proven clinically effective in patients with AML with FLT3 internal tandem duplication (ITD) mutations, but inhibitors of other pathologically activated kinases in AML such as c-KIT and JAK2 have achieved less clinical success. quizartinib fms related receptor tyrosine kinase 3 Homo sapiens
3 Recently, selective and potent FLT3 inhibitors such as AC220 (quizartinib) have proven clinically effective in patients with AML with FLT3 internal tandem duplication (ITD) mutations, but inhibitors of other pathologically activated kinases in AML such as c-KIT and JAK2 have achieved less clinical success. quizartinib fms related receptor tyrosine kinase 3 Homo sapiens
4 Recently, selective and potent FLT3 inhibitors such as AC220 (quizartinib) have proven clinically effective in patients with AML with FLT3 internal tandem duplication (ITD) mutations, but inhibitors of other pathologically activated kinases in AML such as c-KIT and JAK2 have achieved less clinical success. quizartinib fms related receptor tyrosine kinase 3 Homo sapiens