Title : Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice.

Pub. Date : 2013 Sep 5

PMID : 23707980






2 Functional Relationships(s)
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1 Chronic morphine also increases IL-1beta expression in GFAP-expressing astrocytes, which is abolished in tPA-deficient mice. Morphine interleukin 1 beta Mus musculus
2 In cultured astrocytes, morphine treatment increases tPA, IL-1beta, and pERK expression, and the increased IL-1beta and pERK expression is abolished in tPA-deficient astrocytes. Morphine interleukin 1 beta Mus musculus