Title : Prometaphase arrest-dependent phosphorylation of Bcl-2 family proteins and activation of mitochondrial apoptotic pathway are associated with 17α-estradiol-induced apoptosis in human Jurkat T cells.

Pub. Date : 2013 Oct

PMID : 23707954






3 Functional Relationships(s)
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1 Prometaphase arrest-dependent phosphorylation of Bcl-2 family proteins and activation of mitochondrial apoptotic pathway are associated with 17alpha-estradiol-induced apoptosis in human Jurkat T cells. alfatradiol BCL2 apoptosis regulator Homo sapiens
2 In Jurkat T cell clone (JT/Neo), G2/M arrest, apoptotic sub-G1 peak, mitochondrial membrane potential (Deltapsim) loss, and TUNEL-positive DNA fragmentation were induced following exposure to 17alpha-estradiol (17alpha-E2), whereas none of these events (except for G2/M arrest) were induced in Jurkat cells overexpressing Bcl-2 (JT/Bcl-2). alfatradiol BCL2 apoptosis regulator Homo sapiens
3 In Jurkat T cell clone (JT/Neo), G2/M arrest, apoptotic sub-G1 peak, mitochondrial membrane potential (Deltapsim) loss, and TUNEL-positive DNA fragmentation were induced following exposure to 17alpha-estradiol (17alpha-E2), whereas none of these events (except for G2/M arrest) were induced in Jurkat cells overexpressing Bcl-2 (JT/Bcl-2). alfatradiol BCL2 apoptosis regulator Homo sapiens