Pub. Date : 2013 Aug
PMID : 23706331
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To investigate the action of nuclear factor (NF)-kappaB in adenomyosis and evaluate the potential therapeutic effect of andrographolide on tumor necrosis factor (TNF)-alpha-induced expression of NF-kappaB-mediated genes cyclooxygease-2 (COX-2), vascular endothelial growth factor (VEGF), and tissue factor (TF) in adenomyotic stromal cells. | andrographolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | MAIN OUTCOME MEASURE(S): The NF-kappaB DNA-binding activity and protein levels of NF-kappaB subunits p50 and p65 and the messenger RNA (mRNA) and protein levels of NF-kappaB-mediated genes COX-2, VEGF, and TF in cases and controls, and their changes after stimulation with TNF-alpha and treatment with andrographolide. | andrographolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | MAIN OUTCOME MEASURE(S): The NF-kappaB DNA-binding activity and protein levels of NF-kappaB subunits p50 and p65 and the messenger RNA (mRNA) and protein levels of NF-kappaB-mediated genes COX-2, VEGF, and TF in cases and controls, and their changes after stimulation with TNF-alpha and treatment with andrographolide. | andrographolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | MAIN OUTCOME MEASURE(S): The NF-kappaB DNA-binding activity and protein levels of NF-kappaB subunits p50 and p65 and the messenger RNA (mRNA) and protein levels of NF-kappaB-mediated genes COX-2, VEGF, and TF in cases and controls, and their changes after stimulation with TNF-alpha and treatment with andrographolide. | andrographolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Targeting NF-kappaB with inhibitors, like andrographolide, may hold promises of treating adenomyosis. | andrographolide | nuclear factor kappa B subunit 1 | Homo sapiens |