Title : Drug-drug interactions between HMG-CoA reductase inhibitors (statins) and antiviral protease inhibitors.

Pub. Date : 2013 Oct

PMID : 23703578






3 Functional Relationships(s)
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1 Drug-drug interactions are dependent on statins" pharmacokinetic profile: simvastatin, lovastatin and atorvastatin are metabolized through cytochrome P450 (CYP) 3A, while the metabolism of the other statins is independent of this CYP. Simvastatin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Simvastatin and lovastatin metabolized through CYP3A have the highest potency for drug-drug interaction with potent CYP3A inhibitors such as ritonavir- or cobicistat-boosted HIV-PI or the hepatitis C virus (HCV) PI, telaprevir or boceprevir, and therefore their coadministration is contraindicated. Simvastatin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 Simvastatin and lovastatin metabolized through CYP3A have the highest potency for drug-drug interaction with potent CYP3A inhibitors such as ritonavir- or cobicistat-boosted HIV-PI or the hepatitis C virus (HCV) PI, telaprevir or boceprevir, and therefore their coadministration is contraindicated. Simvastatin cytochrome P450 family 3 subfamily A member 4 Homo sapiens