Title : Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats.

Pub. Date : 2013 Jul 10

PMID : 23702423






1 Functional Relationships(s)
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1 More notably, DH+IS rats showed significantly increased diameter of cardiomyocytes, increased fibrotic area, increased staining for TGF-beta1, SMA, type 1 collagen, Nox4, 8-OHdG and MDA, and decreased staining for Nrf2 and HO-1 in the heart compared with DH. 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole transforming growth factor, beta 1 Rattus norvegicus