Pub. Date : 2013 Sep
PMID : 23686330
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 2 | METHODS: A total of 109 patients treated with morphine were genotyped by DNA sequencing for 12 DNA polymorphisms of the COMT, OPRM1 and UGT2B7 genes. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 3 | RESULTS: An association between average morphine consumption during the first 24 postoperative hours by patient-controlled analgesia (PCA) and COMT haplotypes was found. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 4 | CONCLUSIONS: By considering COMT, OPRM1, and UGT2B7 genotypes, as well as pharmacokinetic results, only COMT polymorphisms appear to be predictive of morphine need in postoperative pain therapy. | Morphine | catechol-O-methyltransferase | Homo sapiens |