Pub. Date : 2013 Aug
PMID : 23684072
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | In contrast, an ROS inhibitor prevented the anti-Siglec-8/IL-5-induced enhancement of ERK phosphorylation and cell death. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Collectively, these data suggest that the enhancement of ERK phosphorylation is downstream of ROS generation. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | CONCLUSIONS: In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |