Pub. Date : 2013 May 16
PMID : 23681233
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Taxol also induced c-Jun N-terminal kinase (JNK) activation and phosphorylation of its substrates B-cell CLL/lymphoma 2 (Bcl2) and BCL2-like 1 (BclXL) under normoxia and hypoxia very early after taxol exposure. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Taxol also induced c-Jun N-terminal kinase (JNK) activation and phosphorylation of its substrates B-cell CLL/lymphoma 2 (Bcl2) and BCL2-like 1 (BclXL) under normoxia and hypoxia very early after taxol exposure. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | The results showed that JNK activation promotes resistance against taxol-induced apoptosis under normoxia and hypoxia without being involved in induction of autophagy. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | In conclusion, the resistance against taxol-induced cell death observed under hypoxia can be explained by a more effective autophagic flow activated via the classical mTOR pathway and by a mechanism involving JNK, which could be dependent on Bcl2 and BclXL phosphorylation but independent of JNK-induced autophagy activation. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | In conclusion, the resistance against taxol-induced cell death observed under hypoxia can be explained by a more effective autophagic flow activated via the classical mTOR pathway and by a mechanism involving JNK, which could be dependent on Bcl2 and BclXL phosphorylation but independent of JNK-induced autophagy activation. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |