Pub. Date : 2013 Oct
PMID : 23680185
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In human hepatocytes, the activation of FXR with the agonist GW4064 resulted in a significant protection against cisplatin-induced toxicity. | GW 4064 | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
2 | In human hepatoma Alexander cells, with negligible endogenous expression of FXR, GW4064 also protected against cisplatin-induced toxicity, but only if they were previously transfected with FXR/RXR. | GW 4064 | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
3 | In both models, cisplatin, even in the absence of FXR agonists, such as bile acids and GW4064, was able to up-regulate FXR targets genes, which was due to FXR-mediated trans-activation of response elements in the promoter region. | GW 4064 | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
4 | In both models, cisplatin, even in the absence of FXR agonists, such as bile acids and GW4064, was able to up-regulate FXR targets genes, which was due to FXR-mediated trans-activation of response elements in the promoter region. | GW 4064 | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |