Title : Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds.

Pub. Date : 2013 Oct

PMID : 23680185






4 Functional Relationships(s)
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1 In human hepatocytes, the activation of FXR with the agonist GW4064 resulted in a significant protection against cisplatin-induced toxicity. GW 4064 nuclear receptor subfamily 1 group H member 4 Homo sapiens
2 In human hepatoma Alexander cells, with negligible endogenous expression of FXR, GW4064 also protected against cisplatin-induced toxicity, but only if they were previously transfected with FXR/RXR. GW 4064 nuclear receptor subfamily 1 group H member 4 Homo sapiens
3 In both models, cisplatin, even in the absence of FXR agonists, such as bile acids and GW4064, was able to up-regulate FXR targets genes, which was due to FXR-mediated trans-activation of response elements in the promoter region. GW 4064 nuclear receptor subfamily 1 group H member 4 Homo sapiens
4 In both models, cisplatin, even in the absence of FXR agonists, such as bile acids and GW4064, was able to up-regulate FXR targets genes, which was due to FXR-mediated trans-activation of response elements in the promoter region. GW 4064 nuclear receptor subfamily 1 group H member 4 Homo sapiens