Title : Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.

Pub. Date : 2013 Jun 13

PMID : 23679955






2 Functional Relationships(s)
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1 Among the 7-unsubstituted coumarins selective, competitive GPR55 antagonists were identified, such as 3-(2-hydroxybenzyl)-5-isopropyl-8-methyl-2H-chromen-2-one (12, PSB-SB-489, IC50 = 1.77 muM, pA2 = 0.547 muM). Coumarins latexin Homo sapiens
2 Among the 7-unsubstituted coumarins selective, competitive GPR55 antagonists were identified, such as 3-(2-hydroxybenzyl)-5-isopropyl-8-methyl-2H-chromen-2-one (12, PSB-SB-489, IC50 = 1.77 muM, pA2 = 0.547 muM). Coumarins latexin Homo sapiens