Pub. Date : 2013 Jun 28
PMID : 23677995
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SAMHD1, a dGTP-regulated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase, down-regulates dNTP pools in terminally differentiated and quiescent cells, thereby inhibiting HIV-1 infection at the reverse transcription step. | deoxyguanosine triphosphate | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 2 | Further, we provide evidence that Vpx binding to SAMHD1 inhibits its catalytic activity and induces disassembly of a dGTP-dependent oligomer. | deoxyguanosine triphosphate | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |