Pub. Date : 2013 Aug
PMID : 23677648
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A new recombinant MnSOD prevents the cyclosporine A-induced renal impairment. | Cyclosporine | superoxide dismutase 2 | Rattus norvegicus |
| 2 | The present study aims to investigate in vivo the effects of a new recombinant mitochondrial manganese-containing superoxide dismutase (rMnSOD), a strong antioxidant, on the CsA-induced nephotoxicity. | Cyclosporine | superoxide dismutase 2 | Rattus norvegicus |
| 3 | RESULTS: CsA-treated rats showed a severe decrease in GFR (0.34 +- 0.17 versus 0.94 +- 0.10 in control, P < 0.001) which was prevented by rMnSOD co-administration (0.77 +- 0.10). | Cyclosporine | superoxide dismutase 2 | Rattus norvegicus |
| 4 | CONCLUSIONS: Administration of rMnSOD prevents CsA-mediated impairment of the GFR along with morphological alteration. | Cyclosporine | superoxide dismutase 2 | Rattus norvegicus |