Title : Assembly of the TLR2/6 transmembrane domains is essential for activation and is a target for prevention of sepsis.

Pub. Date : 2013 Jun 15

PMID : 23677476






1 Functional Relationships(s)
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1 Secretion of the cytokines TNF-alpha and IL-6 by cultured macrophages (RAW264.7 cell line) was inhibited by these peptides in response to TLR2 activation by lipoteichoic acid (TLR2/6 activator) or palmitoyl (3)-Cys-Ser-Lys(4)-OH (TLR2/1 activator) but not by LPS (TLR4 activator). lipoteichoic acid interleukin 6 Mus musculus