Title : Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling.

Pub. Date : 2013 Apr 20

PMID : 23671446






2 Functional Relationships(s)
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1 In addition, this sedative drug inhibited PMA-induced levels of phos-ERK (1.243 +-0.12, 1.108 +-0.16 and 0.903 +-0.19, respectively) and phos-p38 (1.146 +-0.10, 1.063 +-0.13 and 0.946 +-0.18, at concentrations of (5, 10 and 20 microM), respectively. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens
2 CONCLUSIONS: These results are important for understanding the mechanism of midazolam in inhibiting PMA-induced MMP expression through the signaling pathways of either NF-kappaB or ERK/p38 MAPKs down-regulation. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens