Pub. Date : 2013 Apr 20
PMID : 23671445
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Valproic acid upregulates NKG2D ligand expression and enhances susceptibility of human renal carcinoma cells to NK cell-mediated cytotoxicity. | Valproic Acid | killer cell lectin like receptor K1 | Homo sapiens |
| 2 | INTRODUCTION: We aimed to investigate the effect of valproic acid (VPA) on NKG2D ligand expression in human renal carcinoma cell lines and to investigate the mechanisms. | Valproic Acid | killer cell lectin like receptor K1 | Homo sapiens |
| 3 | INTRODUCTION: We aimed to investigate the effect of valproic acid (VPA) on NKG2D ligand expression in human renal carcinoma cell lines and to investigate the mechanisms. | Valproic Acid | killer cell lectin like receptor K1 | Homo sapiens |
| 4 | Real-time PCR and FCM were used to detect the changes of mRNA and protein level of NKG2D ligands (MICA/B and ULBPs) in the two cell lines treated with 4 mM VPA. | Valproic Acid | killer cell lectin like receptor K1 | Homo sapiens |
| 5 | 786-O and ACHN cells treated with VPA were more susceptible to killing by NK cells than untreated cells and the enhanced cytotoxicity of NK cells was blocked by the pretreatment of NK cells with anti-NKG2D monoclonal antibodies (p < 0.05). | Valproic Acid | killer cell lectin like receptor K1 | Homo sapiens |
| 6 | CONCLUSIONS: Valproic acid can clearly induce the expression of NKG2D ligands of renal carcinoma cell lines, thereby enhancing the cytotoxicity of NK cells against renal carcinoma cell lines. | Valproic Acid | killer cell lectin like receptor K1 | Homo sapiens |