Pub. Date : 2013 Jul
PMID : 23670355
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicorandil inhibits hypoxia-induced apoptosis in human pulmonary artery endothelial cells through activation of mitoKATP and regulation of eNOS and the NF-kappaB pathway. | Nicorandil | nitric oxide synthase 3 | Homo sapiens |
| 2 | However, these protective effects of nicorandil were significantly inhibited by an antagonist of mitochondrial adenosine triphosphate-sensitive potassium (mitoKATP) channels, 5-hydroxydecanoate (5-HD, 500 microM), and by an eNOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME, 300 microM). | Nicorandil | nitric oxide synthase 3 | Homo sapiens |
| 3 | We further observed that nicorandil could upregulate the decreased protein expression of eNOS and IkappaBalpha, and downregulate the increased protein expression of NF-kappaB, induced by hypoxia. | Nicorandil | nitric oxide synthase 3 | Homo sapiens |
| 4 | Collectively, these findings suggest that nicorandil inhibits hypoxia-induced apoptosis of HPAECs through activation of mitoKATP channels and increased eNOS expression, which in turn inhibits the NF-kappaB pathway and the mitochondrial apoptotic pathway. | Nicorandil | nitric oxide synthase 3 | Homo sapiens |