Pub. Date : 2013 Sep
PMID : 23661232
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effects of resveratrol on MCP-1, IL-6, and IL-8 production in human coronary artery smooth muscle cells. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | Basal levels of monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6, and IL-8 were significantly decreased in the presence of resveratrol at 1-50 muM in a concentration-dependent manner and were significantly decreased in the presence of U0126, an ERK inhibitor. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | Basal levels of monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6, and IL-8 were significantly decreased in the presence of resveratrol at 1-50 muM in a concentration-dependent manner and were significantly decreased in the presence of U0126, an ERK inhibitor. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | Resveratrol significantly decreased both basal and interferon-gamma (IFN-gamma) (200 ng/ml)-stimulated levels of MCP-1, IL-6, and IL-8 and significantly attenuated both basal and IFN-gamma-stimulated activity of ERK. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | Therefore, resveratrol is thought to inhibit production of MCP-1, IL-6, and IL-8 in HCASMCs through attenuating ERK activity. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |