Pub. Date : 2013 Jul
PMID : 23660976
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 2 | We show here that cisplatin-induced apoptosis is defective in the renal proximal tubule cells (RPTC) from the Abl(mu/mu) mice. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 3 | When injected with cisplatin, we found similar levels of platinum in the Abl(+/+) and the Abl(mu/mu) kidneys, as well as similar initial inductions of p53 and PUMAalpha expression. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 4 | When injected with cisplatin, we found similar levels of platinum in the Abl(+/+) and the Abl(mu/mu) kidneys, as well as similar initial inductions of p53 and PUMAalpha expression. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 5 | Co-treatment of cisplatin with the Abl kinase inhibitor, imatinib, reduced the accumulation of p53 and PUMAalpha in the Abl(+/+) but not in the Abl(mu/mu) kidneys. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 6 | Co-treatment of cisplatin with the Abl kinase inhibitor, imatinib, reduced the accumulation of p53 and PUMAalpha in the Abl(+/+) but not in the Abl(mu/mu) kidneys. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 7 | Co-treatment of cisplatin with the Abl kinase inhibitor, imatinib, reduced the accumulation of p53 and PUMAalpha in the Abl(+/+) but not in the Abl(mu/mu) kidneys. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 8 | These results provide in vivo evidence for the pro-apoptotic function of Abl, and show that its nuclear localization and tyrosine kinase activity are both required for the sustained expression of p53 and PUMAalpha in cisplatin-induced renal apoptosis. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |