Pub. Date : 1990 Jul 15
PMID : 2365995
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The regulatory effect of H2O2 on both the cytotoxic activity and the specific binding of TNF-alpha was studied by using TNF-alpha-sensitized murine L929 cells. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 2 | The regulatory effect of H2O2 on both the cytotoxic activity and the specific binding of TNF-alpha was studied by using TNF-alpha-sensitized murine L929 cells. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 3 | When these cells were exposed simultaneously to TNF-alpha and H2O2 (100 to 500 microM), the cytotoxic activity of TNF-alpha was inhibited by up to 66.6%. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 4 | These data suggest that H2O2 altered the cell sensitivity to TNF-alpha, without modifying the activity of the TNF-alpha molecule. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 5 | Maximum loss of cell sensitivity to TNF-alpha occurred after 30-min preexposure to 500 microM H2O2. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 6 | Complete restoration of TNF-alpha sensitivity was obtained within 12 h after H2O2 removal. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 7 | In contrast, H2O2 effect was associated with an about 50% loss of the density of cell membrane 125I-TNF-alpha receptors (2949 vs 5620 binding sites per cell), without change in their affinity (3.9 vs 3.4 nM). | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 8 | Moreover H2O2 did not affect the rate of degradation of TNF-alpha, and only slightly increased the degree of internalization of 125I-TNF-alpha receptors. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 9 | These findings indicate that H2O2 can down-regulate the cellular response to TNF-alpha, possibly by reducing the TNF-alpha-binding capacity. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 10 | These findings indicate that H2O2 can down-regulate the cellular response to TNF-alpha, possibly by reducing the TNF-alpha-binding capacity. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |