Pub. Date : 2013
PMID : 23658699
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insulin-mediated activation of the L-arginine nitric oxide pathway in man, and its impairment in diabetes. | Arginine | insulin | Homo sapiens |
| 2 | Given that cardiovascular diseases are also associated with insulin resistance, and insulin is known to induce vasodilation via a NO-dependent pathway, we hypothesised that abnormal insulin modulation of L-arginine transport may contribute to vascular dysfunction in diabetes. | Arginine | insulin | Homo sapiens |
| 3 | Given that cardiovascular diseases are also associated with insulin resistance, and insulin is known to induce vasodilation via a NO-dependent pathway, we hypothesised that abnormal insulin modulation of L-arginine transport may contribute to vascular dysfunction in diabetes. | Arginine | insulin | Homo sapiens |
| 4 | The effect of locally delivered insulin on arginine transport was assessed during an intra-arterial infusion of [4,5-(3)H] L-arginine. | Arginine | insulin | Homo sapiens |
| 5 | CONCLUSION: These findings suggest that insulin resistance may contribute substantially to the onset and development of cardiovascular disease in type 2 diabetics via abnormal insulin-mediated regulation of L-arginine transport. | Arginine | insulin | Homo sapiens |