Title : Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways.

Pub. Date : 2013 Jul 15

PMID : 23643895






3 Functional Relationships(s)
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1 We have previously shown that cholesterol stimulation leads to PI3K/Akt phosphorylation, and now demonstrated that cholesterol inhibits ERK1/2 phosphorylation; both effects reversed when cholesterol is depleted from lipid rafts using methyl-beta-cyclodextrin (MBCD). Cholesterol mitogen-activated protein kinase 3 Mus musculus
2 We have previously shown that cholesterol stimulation leads to PI3K/Akt phosphorylation, and now demonstrated that cholesterol inhibits ERK1/2 phosphorylation; both effects reversed when cholesterol is depleted from lipid rafts using methyl-beta-cyclodextrin (MBCD). Cholesterol mitogen-activated protein kinase 3 Mus musculus
3 In addition, vanadate, an inhibitor of phosphatases, reversed the cholesterol inhibition of ERK1/2 phosphorylation. Cholesterol mitogen-activated protein kinase 3 Mus musculus