Pub. Date : 2013 Jun 21
PMID : 23643633
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interestingly, urinary VEGF levels were also significantly decreased in the sulodexide-treated group. | glucuronyl glucosamine glycan sulfate | vascular endothelial growth factor A | Rattus norvegicus |
| 2 | In accordance with UAE and urinary VEGF changes, the renal expression of profibrotic molecules was significantly decreased after sulodexide treatment. | glucuronyl glucosamine glycan sulfate | vascular endothelial growth factor A | Rattus norvegicus |
| 3 | In cultured podocytes, sulodexide treatment significantly decreased high glucose-induced p38 MAPK activation and VEGF synthesis. | glucuronyl glucosamine glycan sulfate | vascular endothelial growth factor A | Rattus norvegicus |
| 4 | SIGNIFICANCE: Sulodexide directly suppresses VEGF synthesis through the p38 MAPK pathway in podocytes, and these results suggest that sulodexide may provide renoprotection via suppression of renal VEGF synthesis independently of glomerular basement membrane ionic permselectivity in type 2 diabetic rats. | glucuronyl glucosamine glycan sulfate | vascular endothelial growth factor A | Rattus norvegicus |
| 5 | SIGNIFICANCE: Sulodexide directly suppresses VEGF synthesis through the p38 MAPK pathway in podocytes, and these results suggest that sulodexide may provide renoprotection via suppression of renal VEGF synthesis independently of glomerular basement membrane ionic permselectivity in type 2 diabetic rats. | glucuronyl glucosamine glycan sulfate | vascular endothelial growth factor A | Rattus norvegicus |