Pub. Date : 2013 Jun
PMID : 23642436
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cardioprotective mechanism of diazoxide involves the inhibition of succinate dehydrogenase. | Diazoxide | succinate dehydrogenase complex iron sulfur subunit B | Homo sapiens |
| 2 | Diazoxide may be cardioprotective due to the inhibition of SDH which may form a portion of the mitochondrial KATP channel. | Diazoxide | succinate dehydrogenase complex iron sulfur subunit B | Homo sapiens |
| 3 | METHODS: SDH activity was measured in isolated mitochondria exposed to succinate (control), malonate (inhibitor of succinate dehydrogenase), diazoxide, and varying concentrations of glutathione alone or in combination with diazoxide. | Diazoxide | succinate dehydrogenase complex iron sulfur subunit B | Homo sapiens |
| 4 | METHODS: SDH activity was measured in isolated mitochondria exposed to succinate (control), malonate (inhibitor of succinate dehydrogenase), diazoxide, and varying concentrations of glutathione alone or in combination with diazoxide. | Diazoxide | succinate dehydrogenase complex iron sulfur subunit B | Homo sapiens |
| 5 | RESULTS: Both malonate and diazoxide inhibited succinate dehydrogenase. | Diazoxide | succinate dehydrogenase complex iron sulfur subunit B | Homo sapiens |
| 6 | Glutathione prevented the inhibition of succinate dehydrogenase by diazoxide in a dose-dependent manner. | Diazoxide | succinate dehydrogenase complex iron sulfur subunit B | Homo sapiens |
| 7 | CONCLUSIONS: The ability of diazoxide to provide beneficial myocyte homeostasis during stress involves the inhibition of succinate dehydrogenase, which may also involve the opening of a purported mitochondrial adenosine triphosphate sensitive potassium channel. | Diazoxide | succinate dehydrogenase complex iron sulfur subunit B | Homo sapiens |