Pub. Date : 2013 Jun 15
PMID : 23640974
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Genetic variants of paclitaxel pharmacokinetics tested were CYP3A4*22, CYP2C8*3, CYP2C8*4, and ABCB1 3435 C>T. The association between CYP3A4*22 and neurotoxicity observed in the exploratory cohort was validated in an independent patient cohort (n = 239). | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Genetic variants of paclitaxel pharmacokinetics tested were CYP3A4*22, CYP2C8*3, CYP2C8*4, and ABCB1 3435 C>T. The association between CYP3A4*22 and neurotoxicity observed in the exploratory cohort was validated in an independent patient cohort (n = 239). | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | In this study, female CYP3A4*22 carriers had increased risk of developing severe neurotoxicity during paclitaxel therapy. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |