Pub. Date : 2013 Nov
PMID : 23640035
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice. | Silicon Dioxide | interleukin 1 beta | Mus musculus |
| 2 | Interleukin-1 beta (IL-1beta) plays an important role in silica-induced lung inflammation, but the mechanisms that underlie the influence of IL-1beta on the progression of silicosis remain unclear. | Silicon Dioxide | interleukin 1 beta | Mus musculus |
| 3 | Interleukin-1 beta (IL-1beta) plays an important role in silica-induced lung inflammation, but the mechanisms that underlie the influence of IL-1beta on the progression of silicosis remain unclear. | Silicon Dioxide | interleukin 1 beta | Mus musculus |
| 4 | In this study, the role of IL-1beta in silica-induced inflammation and fibrosis was evaluated by administering a suspension of 2.5-mg silica dust, either with or without 40 mug anti-mouse IL-1beta monoclonal antibody (mAb), to the lungs of male C57BL/6 mice. | Silicon Dioxide | interleukin 1 beta | Mus musculus |
| 5 | Silica + anti-IL-1beta mAb-treated mice showed the depletion of IL-1beta as well as the attenuation of inflammation, as evaluated in the bronchoalveolar lavage fluid (BALF) and histological sections from 1 to 84 days after silica exposure. | Silicon Dioxide | interleukin 1 beta | Mus musculus |
| 6 | Silica + anti-IL-1beta mAb-treated mice showed the depletion of IL-1beta as well as the attenuation of inflammation, as evaluated in the bronchoalveolar lavage fluid (BALF) and histological sections from 1 to 84 days after silica exposure. | Silicon Dioxide | interleukin 1 beta | Mus musculus |
| 7 | Silica + anti-IL-1beta mAb-treated mice showed the depletion of IL-1beta as well as the attenuation of inflammation, as evaluated in the bronchoalveolar lavage fluid (BALF) and histological sections from 1 to 84 days after silica exposure. | Silicon Dioxide | interleukin 1 beta | Mus musculus |
| 8 | The real-time PCR and pathology results showed that the neutralization of IL-1beta attenuated silica-induced fibrosis by inhibiting the gene expression of transforming growth factor-beta 1, collagen I and fibronectin. | Silicon Dioxide | interleukin 1 beta | Mus musculus |
| 9 | In conclusion, the present study suggests that the neutralization of IL-1beta attenuates silica-induced inflammation and fibrosis by inhibiting other inflammatory and fibrogenic mediators and modulating the Th1/Th2 balance. | Silicon Dioxide | interleukin 1 beta | Mus musculus |