Pub. Date : 2013 Sep
PMID : 23639433
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The objective of this study was to determine the effects of ethanol self-administration and nicotine treatment, alone and in combination, on brain CYP2B6 and CYP2E1 levels in monkeys. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Immunocytochemistry revealed induction of both CYP2B6 and CYP2E1 protein in certain brain regions and cells within monkey brain as a result of ethanol self-administration, nicotine treatment and combined exposure to both drugs. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Combined ethanol and nicotine exposure induced CYP2B6 in the caudate, putamen, thalamus and cerebellum (1.4-2.4 fold, P < 0.05), and CYP2E1 in the frontal cortex and putamen (1.5-1.8, P < 0.05). | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | In summary, ethanol and nicotine can induce CYP2B6 and CYP2E1 protein in the primate brain, which could potentially result in altered sensitivity to centrally acting drugs and toxins. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |