Title : p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure.

Pub. Date : 2013 Sep

PMID : 23639288






1 Functional Relationships(s)
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1 Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner. arsenite heat shock protein family A (Hsp70) member 4 Homo sapiens