Pub. Date : 2013 Jun
PMID : 23636660
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because Congo red (CR) can bind to critical intermediate structural forms of amyloid beta (Abeta), it has been suggested as a potential therapeutic agent against neurodegenerative disorders such as Alzheimer"s disease. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 2 | Because Congo red (CR) can bind to critical intermediate structural forms of amyloid beta (Abeta), it has been suggested as a potential therapeutic agent against neurodegenerative disorders such as Alzheimer"s disease. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 3 | Because Congo red (CR) can bind to critical intermediate structural forms of amyloid beta (Abeta), it has been suggested as a potential therapeutic agent against neurodegenerative disorders such as Alzheimer"s disease. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 4 | Because Congo red (CR) can bind to critical intermediate structural forms of amyloid beta (Abeta), it has been suggested as a potential therapeutic agent against neurodegenerative disorders such as Alzheimer"s disease. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 5 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 6 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 7 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 8 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 9 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 10 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 11 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 12 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 13 | Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. | Congo Red | amyloid beta precursor protein | Homo sapiens |
| 14 | In fact, no CR binding was observed at 35 C. The binding of CR to Abeta(12-28) was associated with favorable changes in both enthalpy and entropy that resulted in binding constants (K) of between 10(5) and 10(6) M (-1). | Congo Red | amyloid beta precursor protein | Homo sapiens |