Pub. Date : 2013 Aug
PMID : 23636169
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin was used to decrease VEGF-A and MMP-9 gene expression in our murine arteriovenous fistula model created by connecting the right carotid artery to the ipsilateral jugular vein. | Simvastatin | vascular endothelial growth factor A | Mus musculus |
| 2 | Compared to fistulae of vehicle-treated mice, the fistulae of simvastatin-treated mice had the expected decrease in VEGF-A and MMP-9 but also showed a significant reduction in MMP-2 expression with a significant decrease in VNH and a significant increase in the mean lumen vessel area. | Simvastatin | vascular endothelial growth factor A | Mus musculus |
| 3 | Thus, simvastatin results in a significant reduction in VNH, with increase in mean lumen vessel area by decreasing VEGF-A/MMP-9 pathway activity. | Simvastatin | vascular endothelial growth factor A | Mus musculus |