Title : Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.

Pub. Date : 2013 Jun 14

PMID : 23629654






1 Functional Relationships(s)
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1 By using biotin and [(35)S]methionine labeling, we showed that 17-AAG caused depletion of membrane-localized AXL by mediating its degradation in the intracellular compartment, thus restricting its exposure on the cell surface. Biotin N-methylpurine DNA glycosylase Homo sapiens