Pub. Date : 2013 Aug
PMID : 23624332
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thus, we propose here that hydrogen peroxide (H2O2)-dependent TGF-beta1 regulation may be mediated by ILK activation. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 2 | Thus, we propose here that hydrogen peroxide (H2O2)-dependent TGF-beta1 regulation may be mediated by ILK activation. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 3 | First we confirmed the increase in TGF-beta1 expression in human mesangial cells (HMC) after treatment with H2O2 or with an alternative H2O2-generating system such as the glucose-oxidase enzyme (GOX). | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 4 | First we confirmed the increase in TGF-beta1 expression in human mesangial cells (HMC) after treatment with H2O2 or with an alternative H2O2-generating system such as the glucose-oxidase enzyme (GOX). | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 5 | By using immunoblotting, immunofluorescence, and ELISA techniques, we demonstrate that extracellular H2O2 up-regulates TGF-beta1 transcription, as well as increases TGF-beta1 promoter activity. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 6 | By using immunoblotting, immunofluorescence, and ELISA techniques, we demonstrate that extracellular H2O2 up-regulates TGF-beta1 transcription, as well as increases TGF-beta1 promoter activity. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 7 | Furthermore, catalase-decreased intracellular H2O2 abolished TGF-beta1 up-regulation. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 8 | The use of pharmacological inhibitors as well as knockdown of ILK with small interfering RNA (siRNA) demonstrated the implication of a PI3K/ILK/AKT/ERK MAPK signaling pathway axis in the H2O2-induced TGF-beta1 overexpression. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 9 | In summary, our results provide evidence that ILK activity changes may act as a mechanism in response to different stimuli such as H2O2 in the induced TGF-beta1 up-regulation in pathological or even physiological conditions. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |