Title : Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway.

Pub. Date : 2013 Oct

PMID : 23624305






5 Functional Relationships(s)
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1 Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway. Iron myeloperoxidase Homo sapiens
2 Stopped-flow measurements revealed that the HOCl-mediated MPO heme destruction was complex and occurred through transient ferric species whose formation and decay kinetics indicated it participates in heme destruction along with subsequent free iron release. Iron myeloperoxidase Homo sapiens
3 MPO heme depletion was confirmed by the buildup of free iron utilizing the ferrozine assay. Iron myeloperoxidase Homo sapiens
4 Collectively, this study elucidates the bidirectional relationship between MPO and HOCl, which highlights the potential role of MPO as a source of free iron. Iron myeloperoxidase Homo sapiens
5 Collectively, this study elucidates the bidirectional relationship between MPO and HOCl, which highlights the potential role of MPO as a source of free iron. Iron myeloperoxidase Homo sapiens