Title : Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay.

Pub. Date : 2013 Apr 27

PMID : 23621888






2 Functional Relationships(s)
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1 FINDINGS: We observed that daily intraperitoneal injections of human insulin-like growth factor 1 (IGF-1) over a 2-week period reversed deficits in hippocampal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) signaling, long-term potentiation (LTP), and motor performance that we had previously reported in Shank3-deficient mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid insulin like growth factor 1 Homo sapiens
2 FINDINGS: We observed that daily intraperitoneal injections of human insulin-like growth factor 1 (IGF-1) over a 2-week period reversed deficits in hippocampal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) signaling, long-term potentiation (LTP), and motor performance that we had previously reported in Shank3-deficient mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid insulin like growth factor 1 Homo sapiens